By Richard Nathan
This ebook describes first the ionic currents underlying diastolic depolarization and pacing of the guts. The discussions then shift to the mechanisms of motion of calcium-channel antagonists; the legislation of calcium inflow by means of indigenous elements, corresponding to voltage- or calcium-mediated inactivation; the id of mounted damaging fees at the floor of the sarcolemma; and the legislation of gating and permeability of ion channels via those fees. those subject matters are via interpreting the molecular and ionic mechanisms that underlie the electrophysiologic activities of adrenergic and cholinergic neurotransmitters and peptide hormones. this article extra explores the theoretical and experimental stories of the sodium-calcium alternate procedure, its stoichiometry, and the way the exchanger may well give a contribution to present stream in the course of or after the motion strength. different chapters think about the mechanism of twitch and tonic stress law through cardiac glycosides and intracellular sodium and the way poisonous concentrations result in cardiac arrhythmias. A bankruptcy highlights the id of sarcolemmal binding websites for calcium, the possibility that such binding or the discharge of calcium from
the sarcoplasmic reticulum performs a job within the law of contraction and the discharge of calcium from the sarcoplasmic reticulum. the remainder chapters care for the structural similarities between calcium-binding proteins of the contractile gear and the calcium channel, and the legislation of contraction by means of calcium-binding proteins.
Physiologists, pathophysiologists, clinicians, researchers, and scholars who're attracted to heart’s functionality will locate this booklet invaluable.
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Additional info for Cardiac Muscle: The Regulation Of Excitation And Contraction: The Regulation of Exchange and Contraction (Research Topics in Physiology, Vol 8)
Cardiac Muscle: The Regulation Of Excitation And Contraction: The Regulation of Exchange and Contraction (Research Topics in Physiology, Vol 8) by Richard Nathan